The following are proposed topic areas for the NIH 2007-1 SBIR Contracts Solicitation.

National Cancer Institute (NCI)

• Development of Molecular Pharmacodynamic Assays for Targeted Therapies;
• Synthesis of Stable Isotope-Labeled Steroids as Internal Standards for the Measurement of Endogenous Steroid Hormones in Biologic Samples by Liquid Chromatography ? Mass Spectrometry (LC-MS);
• Quantitative Assay for O6-Carboxymethyl Guanine DNA Adducts;
• Development of Anti-Cancer Agents;
• Development of Software Systems to Facilitate the Use of Electronic Data Records in the Collection of Population-Based Cancer Surveillance Data;
• Develop Automated Methods to Identify Environmental Exposure Patterns in Satellite Imagery Data;
• Home Centered Coordinated Cancer Care System;
• Antibody Array for Cancer;
• Glycan Arrays for Biomarker Discovery and Validation;
• Development of Clinical Automated Multiplex Affinity Capture Technology for Detecting Low Abundance Cancer-related Proteins/Peptides;
• Development of Alternative Affinity Capture Reagents for Cancer Proteomics Research;
• Early Diagnostics Using Nanotechnology-Based Imaging ad Sensing;
• Multifunctional Therapeutics Based on Nanotechnology.

• Ultrasonic Wave Transmitter, Transmission Line and Receiver for Interventional MRI;
• Ultrafine Magnesium Biodegradable Stents for Orphan Disease Applications;
• Critical Technologies for Ventricular Assist Devices;
• Production of Generic Modified Hemoglobin.

• Development of Correlational Alcohol-Relevant Database from Mouse or Rat Transcriptome and Proteome.

• Development of a User-based Information System for Mobility Needs.

• Development Of Science Literacy Materials Or Programs;
• Development of Novel Drug Delivery Systems for Treatment Medications;
• Metabolomics in Drug Abuse Research;
• Marketing Evidence-Based Prevention Interventions for Substance Abuse and Related HIV Prevention;
• Development of State-of-the-Art Mechanisms for Epidemiological Research;
• Automation of the Development of Electronic Data Capture (EDC) System for Clinical Trials Data Collection and Management;
• Development of Practical Training Materials for Evidence-Based Treatment;
• Develop a Real-Time fMRI Feedback System that Allows Drug Abusers to Control their Cravings and Urges and/or Increase their Self-Control of their Drug Taking;
• Design and Synthesis of Treatment Agents for Drug Abuse;
• Mechanisms and Methods to Maximize Data Utilization

• Gene Expression and Molecular Imaging to Identify Early Biomarkers and Staging of Lung Cancer Following Environmental Exposures;
• Quantitative Analysis of Protein Expression in Paraffin Embedded Rodent Tissues;
• High Throughput MRI for Toxicology;
• Development of an ELISA for Measuring Serum Levels of NAG-1/MIC/GDF15;
• Identifying Biomarkers to Predict Renal Disease in Rodent Cancer Bioassays

• Development of Iterative Continuous Clinical Improvement (ICCI) Models for Mental Disorders Utilizing Clinical Trials and other Relevant Research Sources;
• Families as Research and Treatment Partners: Developing Evidence Based Decision Aids for Mental Health Treatment Decisions

Immunization Safety Office (ISO)

• Develop Methods to Enhance Administration of Vaccines, Including Live Virus Vaccines, Through the Respiratory Track;
• Disposable-Cartridge Jet Injector Technology

• Development and Evaluation of Eyewear for Citrus Workers;
• Linking GIS Technology with Essential Public Health Services;
• Tools to Enhance the Utilization of Tobacco Cessation Quitlines

• Development of Novel Genotyping Procedures for Mycobacterium Tuberculosis;
• New Laboratory Tests for Tuberculosis and Detection of Drug Resistance;
• Development of a Novel Information System for Remote TB Control and Prevention Programs

• Generic Targeting of Thrombotic Risk