The following are proposed topic areas for the NIH 2012-1 SBIR Contracts Solicitation.

National Cancer Institute (NCI)

• Development of Anticancer Agents
• Development of Companion Diagnostics
• Development of Radiation Modulators For Use During Radiotherapy
• Reformulation of Cancer Therapeutics using Nanotechnology
• Probing Tumor Microenvironment Using In Vivo Nanotechnology-based Sensors
• Development of Innovative Algorithms for Processing & Analysis of In Vivo Images
• Novel Imaging Agents to Expand the Clinical Toolkit for Cancer Diagnosis, Staging, and Treatment
• Automated Collection, Storage, Analysis, and Reporting Systems for Dietary Images
• Development of Low Cost, Small Sample Multi-Analyte Technologies for Cancer Diagnosis, Prognosis and Early Detection
• Simplified Tissue Microarray Instrument For Clinical and Research Settings (NIH Technology Transfer)
• High Throughput Isolation of Antigen Specific T-cells for Cancer Therapy (NIH Technology Transfer)
• Generation and Qualification of Site-specific Post-translationally Modified Proteins for Use as Calibrators in Pharmacodynamic (PD) Assays.

National Center For Research Resources (NCRR)

• Development of an Integrated Automated High Throughput Platform for Large-Scale Genetic and Therapeutic Screening in Zebrafish.

National Heart, Lung And Blood Institute (NHLBI)

• Development of Induced Pluripotent Stem (iPS) Cell Lines for Use in Cell-based Bioassays
• Novel Technologies for Powering Ventricular Assist Devices
• Reagents for Studying Human Lung Cell Biology and Cellular Function
• Novel Technologies for Assessing Lipoprotein Sub-fractions
• Computer Generated Diet and Exercise Reminders Promoting Cardiovascular Health
• Haptoglobin Treatment to Reduce Complications of Sickle Cell Disease
• Transmit-receive Surface Array Coils for MRI of Patients with Internal Conductive Devices
• Multilayer-coated Gratings for Phase-Contrast Computed Tomography
• Wireless Physiologic Telemetry for Interventional MRI
• Bioabsorbable Stents for Pediatric Pulmonary Artery Stenosis and Aortic Coarctation
• Electrophysiologic Catheters for Interventional MRI Ablation of Ventricular Tachycardia.

National Institute On Alcohol Abuse And Alcoholism (NIAAA)

• Discovery and Preclinical Development of Novel Compounds to Treat Alcohol Use Disorders.
• Development of Novel Compounds to Treat Alcohol Use Disorders.

National Institute Of Diabetes And Digestive And Kidney Diseases (NIDDK)

• A Low Molecular Weight Thyroid-Stimulating Hormone Receptor Agonist for Thyroid Cancer (NIH TT).

National Institute On Drug Abuse (NIDA)

• Confirming Compliance with Experimental Pharmacotherapy Treatment of Drug Abuse
• Development of a Solid Oral Dosage Form for Fenobam
• Recovery Warrior: Behavioral Activation Video Game for Substance Abuse via a Commercially Available Active & Interactive Gaming Platform (e.g., Wii, Play Station Move, or Xbox Kinect)
• Highly Effective Methods for Systemic In Vivo Targeted Delivery of shRNAi to the Brain for Treatment of Substance Use Disorders and Other Brain Disorders
• Feasibility of Development of RNAi-based Therapeutics for Treatment of HIV and HCV Infections in Drug Abusing Populations
• Smokescreen: Genetic Screening Tool for Tobacco Dependence and Treatment Approaches
• Feedback-regulated Naloxone Delivery Device to Prevent Opiate Overdose Deaths
• Drugged Driving: Future Research Directions.

Center For Global Health (GCH)

• The Development of Lateral Flow Immunochromatographic Devices to Detect Antibodies
• Development of a Blood Donor Screening Test to Prevent Transfusion Transmitted Babesiosis.

National Center On Birth Defects And Developmental Disabilities (NCBDDD)

• Development of an Assay to Rapidly Determine Folate Insufficiency in the Field.

National Center For Emerging Zoonotic And Infectious Diseases (NCEZID)

• Vaccine Adverse Event Reporting System (VAERS) Application for Smartphone
• Development of Rapid, Point-of-Care Tests for Diagnosis of Fungal Infections.

National Center For HIV/AIDs, Viral Hepatitis, STD, And TB Prevention (NCHHSTP)

• Testing the Efficacy of HIV Prevention Strategies in Nonhuman Primate Models
• Data Mining Software for Large-Scale Analyses of Infections Caused by Hepatitis Viruses
• Developing a Location-Based Application to Identify Adolescent-Friendly Health Care Services.

Office Of Public Health Preparedness and Response (OPHPR)

• Emergency Vehicle Proximity Alert System.